Probenecid: Inhibits renal excretion of meropenem (MEROMAX 500/MEROMAX 1000) thereby increasing its plasma concentrations and prolonging its elimination half-life. Therefore, the co-administration of probenecid with meropenem (MEROMAX 500/MEROMAX 1000) is not recommended.
Valproic acid: Meropenem (MEROMAX 500/MEROMAX 1000) may reduce serum levels of valproic acid to subtherapeutic levels.